Eirini Karyotaki

Eirini Karyotaki

Research Fellow
e

Dr Karyotaki is a postdoctoral research fellow at Harvard Medical School focusing on examining individual patient differences in response to task-shifted psychotherapy for depression. Overall, her goal is to understand the profiles of individual patients with depression and how these can be tailored to the best treatment options. A central theme in her work has been the great potential of new technological advances, such as Internet-based interventions, in treating adults with depression. In this work, Dr Karyotaki has gathered, synthesised, and analysed data from> 15.000 individual patients across 71 e-health trials on depression. This work has shown important associations between individual patient characteristics and treatment outcomes. 

Dr Karyotaki has participated in several international projects, such as the E-Compared project, which aimed to examine the effects of blended e-health with face-to-face psychotherapy on major depression in primary care. She was the coordinator of a large-scale project on college students’ mental health in the Netherlands, namely the Caring Universities, which involved epidemiological, effectiveness, and implementation research. Further, dr. Karyotaki has been involved in the development and pilot testing of a guided internet-based interventions for college students with common mental disorders in Indonesia, China and the Netherlands.

Along with research, Dr Karyotaki has been a member of the European and International Societies for Research on Internet Interventions (ESRII and ISRII). She has been a keynote speaker at the ESRII 2018 in Ireland and she is a member of the scientific committee of the upcoming ISRII conference in Pittsburgh. Overall, she has (co-) author > 60 peer reviewed publications. 

Key publications

  1. Karyotaki, E, Riper H, Twisk J, Hoogendoorn A, Kleiboer A, Mira A, Mackinnon A, Meyer B, Botella C, Littlewood E, Andersson G, Christensen H, Klein JP, Schroder J, Breton-Lopez J, Scheider J, Griffiths K, Farrer L, Huibers MJ, Phillips R, Gilbody S, Moritz S, Berger T, Pop V, Spek V, Cuijpers P. Efficacy of Self-guided Internet-Based Cognitive Behavioral Therapy in the Treatment of Depressive Symptoms: A Meta-analysis of Individual Participant Data. JAMA psychiatry. 2017; 74:351-359.
  2. Karyotaki, E, Ebert DD, Donkin L, Riper H, Twisk J, Burger S, Rozental A, Lange A, Williams AD, Zarski AC, Geraedts A, van Straten A, Kleiboer A, Meyer B, Unlu Ince BB, Buntrock C, Lehr D, Snoek FJ, Andrews G, Andersson G, Choi I, Ruwaard J, Klein JP, Newby JM, Schroder J, Laferton JAC, Van Bastelaar K, Imamura K, Vernmark K, Boss L, Sheeber LB, Kivi M, Berking M, Titov N, Carlbring P, Johansson R, Kenter R, Perini S, Moritz S, Nobis S, Berger T, Kaldo V, Forsell Y, Lindefors N, Kraepelien M, Bjorkelund C, Kawakami N, Cuijpers P. Do guided internet-based interventions result in clinically relevant changes for patients with depression? An individual participant data meta-analysis. Clinical psychology review. 2018; 63:80-92.
  3. Karyotaki, E, Kemmeren L, Riper H, Twisk J, Hoogendoorn A, Kleiboer A, Mira A, Mackinnon A, Meyer B, Botella C, Littlewood E, Andersson G, Christensen H, Klein JP, Schroder J, Breton-Lopez J, Scheider J, Griffiths K, Farrer L, Huibers MJH, Phillips R, Gilbody S, Moritz S, Berger T, Pop V, Spek V, Cuijpers P. Is self-guided internet-based cognitive behavioural therapy (iCBT) harmful? An individual participant data meta-analysis. Psychological medicine. 2018:1-11.
  4. Karyotaki, E, Kleiboer A, Smit F, Turner DT, Pastor AM, Andersson G, Berger T, Botella C, Breton JM, Carlbring P, Christensen H, de Graaf E, Griffiths K, Donker T, Farrer L, Huibers MJ, Lenndin J, Mackinnon A, Meyer B, Moritz S, Riper H, Spek V, Vernmark K, Cuijpers P. Predictors of treatment dropout in self-guided web-based interventions for depression: an 'individual patient data' meta-analysis. Psychological medicine. 2015; 45:2717-2726.